The role of PKCδ on signal transduction of muscle atrophy

2010 Fiscal Year Final Research Report

• Project/Area Number: 20700559
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Applied health science
• Research Institution: Juntendo University
• Principal Investigator: TAMURA Yoshifumi Juntendo University, 医学部, 准教授 (80420834)
• Project Period (FY): 2008 – 2010
• Keywords: 筋萎縮 / インスリン抵抗性

Research Abstract

(Aim) To clarify the role of PKC-delta on disuse muscle atrophy. (Method) We investigated muscle atrophy and signal transduction of hind-limb model in PKC-delta KO mice. (Result) In PKC-delta KO mice, weight of soleus muscle was lower than those in control mice. Muscle atrophy induced by hind-limb was similar between the groups. (Conclusion) Our result suggested that PKC-delta may contribute to the size of soleus muscle, while it may not affect on disuse muscle atrophy.

Research Products

• [Journal Article] Association of T2 relaxation time determined by magnetic resonance imaging and intramyocellular lipid contents of the soleus muscle in healthy subjects (2010)
  • Author(s): Sakurai Y, Tamura Y, Takeno K, Sato F, Fujitani Y, Hirose T, Kawamori R, Watada H
  • Journal Title: J Diabetes Invest in press
• [Journal Article] Preliminary report : mitochondrial DNA 5178 polymorphism in male elite Japanese endurance runners. (2010)
  • Author(s): Tamura Y, Watada H, Tanaka Y, Daimaru N, Nomiyama T, Sakuraba K, Sawaki K, Kawamori R
  • Journal Title: Metabolism 59 Pages: 62-63
• [Journal Article] Determinants of intramyocellular lipid accumulation after dietary fat loading in non-obese men. (2010)
  • Author(s): Sakurai Y, Tamura Y, Takeno K, Kumashiro N, Sato F, Kakehi S, Ikeda S, Katamoto S, Ogura Y, Saga N, Naito H, Fujitani Y, Hirose T, Kawamori R, Watada H
  • Journal Title: J Diabetes Invest in press
• [Journal Article] Blood flow restriction by low compressive force prevents disuse muscular weakness. (2010)
  • Author(s): Kubota A, Sakuraba K, Koh S, Ogura Y, Tamura Y
  • Journal Title: J Sci Med Sport
• [Journal Article] Effect of resistance exercise training combined with relatively low vascular occlusion. (2009)
  • Author(s): Sumide T, Sakuraba K, Sawaki K, Ohmura H, Tamura Y
  • Journal Title: J Sci Med Sport 12 Pages: 107-112
• [Journal Article] Effects of metformin on peripheral insulin sensitivity and intracellular lipid contents in muscle and liver of overweight Japanese subjects. (2008)
  • Author(s): Tamura Y, Watada H, Sato F, Kumashiro N, Sakurai Y, Hirose T, Tanaka Y, Kawamori R
  • Journal Title: Diabetes Obes Metab 10 Pages: 733-738
• [Journal Article] Short-term effects of dietary fat on intramyocellular lipid in sprinters and endurance runners. (2008)
  • Author(s): Tamura Y, Watada H, Igarashi Y, Nomiyama T, Onishi T, Takahashi K, Doi S, Katamoto S, Hirose T, Tanaka Y, Kawamori R
  • Journal Title: Metabolism 57 Pages: 373-379
• [Journal Article] Efficacy and safety of modified Yale insulin infusion protocol in Japanese diabetic patients after open-heart surgery. (2008)
  • Author(s): Tamaki M, Shimizu T, Kanazawa A, Tamura Y, Hanzawa A, Ebato C, Itou C, Yasunari E, Sanke H, Abe H, Kawai J, Okayama K, Matsumoto K, Komiya K, Kawaguchi M, Inagaki N, Watanabe T, Kanazawa Y, Hirose T, Kawamori R, Watada H
  • Journal Title: Diabetes Res Clin Pract 81 Pages: 296-302
• [Journal Article] Impact of oxidative stress and peroxisome proliferator-activated receptor gamma coactivator-1alpha in hepatic insulin resistance. (2008)
  • Author(s): Kumashiro N, Tamura Y, Uchida T, Ogihara T, Fujitani Y, Hirose T, Mochizuki H, Kawamori R, Watada H
  • Journal Title: Diabetes 57 Pages: 2083-2091
• [Journal Article] Prevention of disuse muscular weakness by restriction of blood flow. (2008)
  • Author(s): Kubota A, Sakuraba K, Sawaki K, Sumide T, Tamura Y
  • Journal Title: Med Sci Sports Exerc 40 Pages: 529-534
• [Presentation] 運動不足・身体不活動と異所性脂肪蓄積:シンポジウム「運動不足・身体不活動と生活習慣病」 (2010)
  • Author(s): 田村好史
  • Organizer: 第65回日本体力医学会
  • Place of Presentation: 千葉(日本)
  • Year and Date: 20100000
• [Presentation] 異所性脂肪からみた適切な運動のあり方:シンポジウム「体質改善を主眼においた最新の生活習慣病治療法開発」 (2010)
  • Author(s): 田村好史
  • Organizer: 第60回体質医学会総会
  • Place of Presentation: 熊本
  • Year and Date: 20100000
• [Presentation] 糖尿病の運動療法 -理論と実際- (2010)
  • Author(s): 田村好史
  • Organizer: In第44回糖尿病学の進歩 社団法人糖尿病学会
  • Place of Presentation: 大阪府大阪市(日本),
  • Year and Date: 20100000
• [Presentation] Diabetes and Exercise :Intramycellular Lipid Accumulation and Insulin Sensitivity. (2009)
  • Author(s): Tamura Y.
  • Organizer: The 15th Korea-Japan Symposium on Diabetes Mellitus Jeju
  • Place of Presentation: Korea
  • Year and Date: 20091120-20091121
• [Presentation] Anatomic and functional imaging of the body (2009)
  • Author(s): Tamura Y.
  • Organizer: US-Japan Nutrition and Metabolism Panel Annual Symposium
  • Place of Presentation: Batton Rouge (US)
  • Year and Date: 20091109-20091110
• [Presentation] 新規インスリン抵抗性規定因子「脂肪負荷感受性仮説」の検証 -proton-MRSを用いた骨格筋細胞内脂質の研究から- (2009)
  • Author(s): 田村好史
  • Organizer: In 福岡大学グローバルFUプログラム
  • Place of Presentation: 福岡県福岡市(日本)
  • Year and Date: 20090000
• [Presentation] 肥満とは独立したインスリン抵抗性規定因子の解明 (2009)
  • Author(s): 田村好史
  • Organizer: In第24回東京臨床肥満研究会
  • Place of Presentation: 東京都中央区(日本)
  • Year and Date: 20090000
• [Presentation] 肝、骨格筋の糖の取り込みの評価法と細胞内脂肪脂質蓄積の関連性 (2009)
  • Author(s): 田村好史
  • Organizer: In第43回糖尿病学の進歩 社団法人日本糖尿病学会
  • Place of Presentation: 長野県松本市(日本)
  • Year and Date: 20090000
• [Presentation] 糖尿病の運動療法 -理論と実際- (2009)
  • Author(s): 田村好史
  • Organizer: In 第59回日本体質医学会総会 日本体質医学会
  • Place of Presentation: 東京都千代田区(日本)
  • Year and Date: 20090000
• [Presentation] ヒトにおける高脂肪食負荷が、骨格筋細胞内脂質蓄積とインスリン抵抗性発生に与える影響とその規定因子 (2009)
  • Author(s): 田村好史, 他
  • Organizer: In第64回日本体力医学会
  • Place of Presentation: 新潟県新潟市(日本)
  • Year and Date: 20090000
• [Presentation] 肝、骨格筋、脂肪のインスリン抵抗性肝細胞内脂肪蓄積-その因果関係と治療戦略- (2008)
  • Author(s): 田村好史
  • Organizer: In 第1回Metabolic-hepatology研究会 Metabolic-hepatology研究会
  • Place of Presentation: 宮城県仙台市(日本)
  • Year and Date: 20080000
• [Presentation] 運動がインスリン抵抗性を改善するメカニズム (2008)
  • Author(s): 田村好史
  • Organizer: In第四回宮崎県糖尿病運動療法研究会 宮崎県糖尿病運動療法研究会
  • Place of Presentation: 宮崎宮崎市(日本)
  • Year and Date: 20080000
• [Remarks] ホームページ等