2009 Fiscal Year Final Research Report
Roles of wingless-related MMTV integration site 5B in type 2 diabetes mellitus
| Project/Area Number |
20700566
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Applied health science
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| Research Institution | The Institute of Physical and Chemical Research |
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Principal Investigator |
KUBOTA Hiroyuki (卯木 浩之) The Institute of Physical and Chemical Research, 内分泌・代謝疾患研究チーム, 研究員 (40323290)
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| Project Period (FY) |
2008 – 2009
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| Keywords | WNT5B / インスリン分泌 / ラ氏島 |
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| Research Abstract |
In this study, we examined the effects of wingless-type mammary tumor virus integration-site family member 5B (WNT5B) on insulin secretion by using islets isolated from mouse. Overexpression of WNT5B in the islets increased both basal and glucose-induced insulin secretion from the islets, however, did not induce insulin expression. From the current study, wnt5b may be involved in the progression of type 2 diabetes by modulating insulin secretion from islets.
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[Journal Article] A Single Nucleotide Polymorphism within the Acetyl-Coenzyme A Carboxylase Beta Gene Is Associated with Proteinuria in Patients with Type 2 Diabetes.2010
Author(s)
Maeda S, Kobayashi MA, Araki S, Babazono T, Freedman BI, Bostrom MA, Cooke JN, Toyoda M, Umezono T, Tarnow L, Hansen T, Gaede P, Jorsal A, Ng DP, Ikeda M, Yanagimoto T, Tsunoda T, Unoki H, Kawai K, Imanishi M, Suzuki D, Shin HD, Park KS, Kashiwagi A, Iwamoto Y, Kaku K, Kawamori R, Parving HH, Bowden DW, Pedersen O, Nakamura Y.
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Journal Title
PLoS Genet. 6(2)
Pages: e1000842
Peer Reviewed
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[Journal Article] The type 2 diabetes associated minor allele of rs2237895 KCNQ1 associates with reduced insulin release following an oral glucose load.2009
Author(s)
Holmkvist J, Banasik K, Andersen G, Unoki H, Jensen TS, Pisinger C, Borch-Johnsen K, Sandbaek A, Lauritzen T, Brunak S, Maeda S, Hansen T, Pedersen O.
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Journal Title
PLoS One 4(6)
Pages: e5872
Peer Reviewed
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[Journal Article] SNPs in KCNQ1 are associated with susceptibility to type 2 diabetes in East Asian and European populations.2008
Author(s)
Unoki H, Takahashi A, Kawaguchi T, Hara K, Horikoshi M, Andersen G, Ng DP, Holmkvist J, Borch-Johnsen K, Jorgensen T, Sandbaek A, Lauritzen T, Hansen T, Nurbaya S, Tsunoda T, Kubo M, Babazono T, Hirose H, Hayashi M, Iwamoto Y, Kashiwagi A, Kaku K, Kawamori R, Tai ES, Pedersen O, Kamatani N, Kadowaki T, Kikkawa R, Nakamura Y, Maeda S.
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Journal Title
Nat Genet. 40(9)
Pages: 1098-102
Peer Reviewed
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[Journal Article] Ang II-stimulated migration of vascular smooth muscle cells is dependent on LR11 in mice.2008
Author(s)
Jiang M, Bujo H, Ohwaki K, Unoki H, Yamazaki H, Kanaki T, Shibasaki M, Azuma K, Harigaya K, Schneider WJ, Saito Y.
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Journal Title
J Clin Invest. 118(8)
Pages: 2733-46
Peer Reviewed
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[Presentation] Identification of a New Susceptibility Gene to Diabetic Nephropathy in Japanese Subjects with Type 2 Diabetes.2009
Author(s)
Unoki H, Kobayashi M, Araki S, Babazono T, Kawai K, Imanishi M, Iwamoto Y, Kashiwagi A, Kawamori R, Nakamura Y, Maeda S.
Organizer
American diabetes association 69th scientific session
Place of Presentation
New Orleans, USA
Year and Date
20090605-20090609
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[Presentation] Identification of a new susceptibility gene to diabetic nephropathy in Japanese subjects with type 2 diabetes.2008
Author(s)
Unoki H, Kobayashi M, Araki S, Ng DP, Babazono T, Kawai K, Imanishi M, Iwamoto Y, Kashiwagi A, Kawamori R, Nakamura Y, Maeda S.
Organizer
The American society of nephrology 42nd Annual Meeting & Scientific Exposition
Place of Presentation
Philadelphia, USA
Year and Date
20081104-20081109
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