2009 Fiscal Year Final Research Report
Association of genetic polymorphisms of ET-1 related genes with progression of target organ damages in hypertensive patients
| Project/Area Number |
20700591
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Eating habits, studies on eating habits
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| Research Institution | Yamagata University |
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Principal Investigator |
BANNO Mariko Yamagata University, 地域教育文化学部, 准教授 (90400530)
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| Project Period (FY) |
2008 – 2009
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| Keywords | 栄養学 / 食品 / 循環器・高血圧 |
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| Research Abstract |
Endothelin-1 (ET-1) system plays a crucial role in vasoconstriction and is a promising target for the genetic analysis of hypertension and its complications. Blood pressure (BP) variations, especially non-dipping patterns during sleep, are known to be associated with progression of cardiovascular target organ damages in hypertensive patients. In this study, we investigated the relationship between single nucleotide polymorphisms (SNPs) in ET-1 related genes and circadian variation of BP in Japanese hypertensives. We genotyped 19 SNPs in ET-1 related genes of 334 essential hypertensive subjects and found that SNPs in ECE2 (G28372A and C28586T) were significantly associated with the non-dipping pattern of BP. We also examined the association between SNPs of ET-1 related genes and prevalence of chronic kidney disease (CKD) complication in Japanese hypertensives. We observed significant association between the SNPs in EDNRA (T54204C, G54240A and A57938G) and CKD in Japanese patients with essential hypertension. Taken together, our results revealed the ET-1 system as an important system involved in target organ damages in essential hypertension in Japanese.
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