2009 Fiscal Year Final Research Report
Inhibitory effect of flavonoids on monocyte adhesion to endothelial cells
| Project/Area Number |
20700592
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Single-year Grants |
|---|
| Research Field |
Eating habits, studies on eating habits
|
|---|
| Research Institution | Ochanomizu University |
|---|
Principal Investigator |
TANI Mariko Ochanomizu University, 生活環境教育研究センター, 研究機関研究員 (90452028)
|
|---|
| Project Period (FY) |
2008 – 2009
|
| Keywords | 健康と食生活 / フラボノイド / 動脈硬化 / 単球接着 |
|---|
| Research Abstract |
Citrus flavonoids such as eriodictyol and hesperetin inhibited monocyte adhesion to endothelial cells via suppressing adhesion molecules by NFkB inactivation. Homocysteine-induced ROS production, expression of anti-oxidant enzyme and inflammatory cytokine, and adhesion to endothelial cells were decreased by citrus flavonoids in monocyte. Citrus flavonoids inhibited the activation of endothelial cells and monocyte, suggesting that their inhibitory effect may contribute to protect against vascular inflammatory.
|
