Preventive effect of silk protein, sericin, on metabolic syndrome

2010 Fiscal Year Final Research Report

• Project/Area Number: 20700597
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Eating habits, studies on eating habits
• Research Institution: Fuji Women's University
• Principal Investigator: OKAZAKI Yukako Fuji Women's University, 人間生活学部, 講師 (80433415)
• Project Period (FY): 2008 – 2010
• Keywords: セリシン / メタボリックシンドローム / アディポサイトカイン / 腸内環境 / 栄養学 / ラット

Research Abstract

This study was performed to examine the effect of dietary sericin on the lipid and carbohydrate metabolisms in rats fed high-fat diet. Consumption of sericin significantly reduced serum and liver lipids and the activities of the lipogenic enzymes. Dietary sericin suppressed the increases in plasma glucose and insulin levels after intraperitoneal glucose injection. Dietary sericin caused a marked elevation in serum adiponectin. These results imply that the increase in serum adiponectin by sericin intake may, at least in part, contribute to the protective effect against hyperlipidemia, fatty liver and glucose intolerance in rats fed a high-fat diet. Consumption of sericin markedly elevated fecal immunoglobulin A (IgA, index of intestinal immune function), mucins (index of intestinal barrier function) and cecal organic aicds in rats fed the high-fat diet. There was an inverse correlation between serum triglyceride and cecal acetate. These results imply that sericin is a useful agent for improving lipid and carbohydrate metabolisms and intestinal luminal environments in rats fed a high-fat diet.

Research Products

• [Journal Article] Consumption of sericin reduces serum lipids, ameliorates glucose tolerance and elevates serum adiponectin in rats fed a high-fat diet. (2010)
  • Author(s): Okazaki, Y., Kakehi, S., Xu, Y., Tsujimoto, K., Sasaki, M., Ogawa, H., Kato, N.
  • Journal Title: Biosci.Biotechnol.Biochem. 74 Pages: 1534-1538
  • Peer Reviewed
• [Presentation] 絹タンパク質セリシンの盲腸有機酸含量と肝障害に及ぼす影響 (2011)
  • Author(s): 岡崎由佳子・辻本和久・佐々木真宏・加藤範久
  • Organizer: 平成23年度日本農芸化学会大会
  • Place of Presentation: 京都
  • Year and Date: 2011-03-27
• [Presentation] 絹タンパク質セリシンの腸内環境に及ぼす影響 (2010)
  • Author(s): 岡崎由佳子・辻本和久・佐々木真宏・加藤範久
  • Organizer: 平成22年度日本農芸化学会大会
  • Place of Presentation: 東京
  • Year and Date: 2010-03-29