2009 Fiscal Year Final Research Report
Screening for anti-aging substances from food and natural product extracts using Saccharomyces cerevisiae mutation assay.
| Project/Area Number |
20700600
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Eating habits, studies on eating habits
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| Research Institution | Tokyo Health Care University |
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Principal Investigator |
SHIMIZU Masatomi Tokyo Health Care University, 医療保健学部, 講師 (90389841)
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| Project Period (FY) |
2008 – 2009
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| Keywords | 抗老化物質 / DNA損傷 / ミトコンドリア / 天然物 / 出芽酵母 / 食品 / 抗変異原物質 / 突然変異 |
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| Research Abstract |
Resveratrol (3,4',5-trihydroxystilbene ; RSV) is a polyphenol found in particularly high concentrations in peanut skin and vine. Here we investigated the anti-mutagenic effects of RSV in Saccharomyces cerevisiae strain 7B. Our results showed that RSV pretreatment for 24 h decreased mutagenesis. Thus the exposure of S. cerevisiae 7B to RSV induces an anti-aging effect. This result raises intense interest for the potentially beneficial effects of RSV on human health.
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