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2009 Fiscal Year Final Research Report

Effects of heavy oil on occurrence of infectious disease and nervous development anomaly

Research Project

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Project/Area Number 20710025
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Environmental impact assessment/Environmental policy
Research InstitutionEhime University

Principal Investigator

KITAMURA Shin-ichi  Ehime University, 沿岸環境科学研究センター, 准教授 (40448379)

Project Period (FY) 2008 – 2009
Keywords重油 / ヒラメ / 感染症 / 神経発生
Research Abstract

In this study, the effects of heavy oil on occurrence of fish infectious disease and nervous development anomaly were investigated. From the result of an experimental infection, we found that heavy oil exposure induced high mortality in viral hemorrhagic septicemia virus (VHSV)-carrier Japanese flounder Paralichthys olivaceus. The expressions of antiviral activity related genes such as interferon and apoptosis induction were relatively lower in the dual group (virus + heavy oil) compared with those of VHSV infection group. Thus, the antiviral activities were suppressed in the fish affected by the dual stressor, which might lead to extensive viral replication in the host cells, resulting in the occurrence of the disease. On the other hand, we observed nervous developmental anomaly in the fish hatched from heavy oil-exposed embryo. From the result of in situ hybridization experiment using sema3A probe, it is suggested that changes of the gene expression profile was responsible for the anomaly.

  • Research Products

    (4 results)

All 2009 2008

All Journal Article (1 results) Presentation (2 results) Book (1 results)

  • [Journal Article] Immune gene expression levels correlate with the phenotype.2008

    • Author(s)
      Jun-Young Song, Kei Nakayama, Yasunor i Murakami, Shin-Ichi Kitamura
    • Journal Title

      Interdisciplinary Studies on Environmental Chemistry-Biol ogical Responses to Chemical Pollutants 1

      Pages: 111-122

    • URL

      http://www.terrapub.co.jp/onlineproceedings/ec/brcp/pdf/BRCP12.pdf

  • [Presentation] Effects of heavy oil pollution on outbreaks of viral disease in fish.2009

    • Author(s)
      Jun-Young Song, Kei Nakayama, Yasunori Murakami, Shin-Ichi Kitamura
    • Organizer
      第15回日本環境毒性学会・バイオアッセイ研究会合同研究発表会
    • Place of Presentation
      東京, 日本
    • Year and Date
      20091018-20091019
  • [Presentation] Effects of heavy oil pollution on outbreaks of fish infectious diseases2009

    • Author(s)
      Jun-Young Song, Kei Nakayama, Yasunori Murakami, Sei-ichi Uno, Jiro Koyama, Shin-Ichi Kitamura
    • Organizer
      Aquaculture Science Meets Environmental Science
    • Place of Presentation
      Ehime University
    • Year and Date
      20090100
  • [Book] Interdisciplinary Studies on Environmental Chemistry Vol. 1:Biological Responses to Chemical Pollutants2008

    • Author(s)
      Yasunori Murakami, Kei Nakayama, Shin-Ichi Kitamura, Hisato Iwata, Shinsuke Tanabe
    • Publisher
      TERRAPUB

URL: 

Published: 2011-06-18   Modified: 2016-04-21  

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