2011 Fiscal Year Final Research Report
A genome-wide expression analysis to study the effects of thyroid-disrupting chmicals on the expression of the hormone responsive genes
| Project/Area Number |
20710051
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Risk sciences of radiation/Chemicals
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| Research Institution | Shizuoka University |
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Principal Investigator |
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| Project Period (FY) |
2008 – 2011
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| Keywords | 内分泌かく乱物質 |
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| Research Abstract |
Hydroxylated polychlorinated are suspected to disrupt post-embryonic neural development in the brains of mammals including humans. Because thyroid hormones play a role in the perinatal development of the central nervous system, the thyroid system is thought to be one of the important endpoints affected by several endocrine-disrupting chemicals including PCBs. We studied the effects of these compounds on thyroid hormone function in the brain by using metamorphosing tadpoles of the African clawed toad as a model for mammalian post-embryonic development. The metamorphosis assay revealed that these compounds inhibit thyroid hormone-induced metamorphosis. Genome-wide gene expression analysis in the brain following short-term exposure demonstrated that delayed metamorphosis could partially be caused by disruption of thyroid hormone-induced gene expression.
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