2009 Fiscal Year Final Research Report
Estrogen-like effects of low-dose Bisphenol A induced by ERRγ receptor heterodimer
| Project/Area Number |
20710053
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Risk sciences of radiation/Chemicals
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| Research Institution | Kyushu University |
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Principal Investigator |
MATSUSHIMA Ayami Kyushu University, 大学院・理学研究院, 助教 (60404050)
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| Project Period (FY) |
2008 – 2009
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| Keywords | 内分泌かく乱物質 / 有害化学物質 / 蛋白質 / 分子認識 / 生体分子 / 核内受容体 / 転写因子 / ビスフェノールA |
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| Research Abstract |
This study revealed that the activity of bisphenol A mediated through the estrogen receptor α (ERα) is increased with coexpression of either estrogen-related receptor α (ERRα) or estrogen-related receptor γ (ERRγ). We newly made several series of plasmids to express dimer receptors of ERRα and ERRγ to analyze the activity of ERα. The results indicated that the activity enhancement is due to the interaction between ERα homodimer αnd ERRα homodimer.
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[Journal Article] Discriminatory synergistic effect of Trp-substitutions in supERαgonist [(Arg/Lys)14, (Arg/Lys)15]nociceptin on ORL1 receptor binding and activation.2009
Author(s)
Nishimura, H., Li, J., Isozaki, K., Okada, K., Matsushima, A., Nose, T., Costa, T., Shimohigashi, Y.
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Journal Title
Bioorg. Med. Chem. 17
Pages: 5683-5687
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[Journal Article] Placenta expressing the greatest quantity of bisphenol A receptor ERRγamong the human reproductive tissues: predominant expression of type-1 ERRγisoform.2009
Author(s)
Takeda, Y., Liu, X., Sumiyoshi, M., Matsushima, A., Shimohigashi, M., Shimohigashi, Y.
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Journal Title
J. Biochem. 146
Pages: 113-122
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[Journal Article] Spare intERαctions of highly potent [Arg14, Lys15]nociceptin for cooperative induction of ORL1 receptor activation.2009
Author(s)
Isozaki, K., Li, J., Okada, K., Nishimura H., Matsushima, A., Nose, T., Costa, T., Shimohigashi, Y.
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Journal Title
Bioorg. Med. Chem. 17
Pages: 7904-7908
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[Journal Article] Induced-fit type ligand binding guided by free-rotatory Leu residue present in the 7thα-helix peptide in the estrogen-related receptorγ(ERRγ).2008
Author(s)
Matsushima, A., Okada, H., Liu, X., Tokunaga, T., TERαmoto, T., Kakuta, Y., Shimohigashi, Y.
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Journal Title
Peptide Science 2008
Pages: 521-522
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[Journal Article] Bisphenol A-specific nuclear receptor ERRγ: structure-function analysis of the two novel isoforms lacking vital peptide fragment in the ligand binding domain.2008
Author(s)
Takeda, Y., Liu, X., Sumiyoshi, M., Matsushima, A., Shimohigashi, Y., Shimohigashi, M.
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Journal Title
Peptide Science 2008
Pages: 517-518
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[Journal Article] Direct evidence revealing structural elements essential for the high binding ability of bisphenol A to human estrogen-related receptorγ(ERRγ).2008
Author(s)
Okada, H., Tokunaga, T., Lui, X., Takayanagi, S., Matsushima, A., Shimohigashi, Y.
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Journal Title
Environ. Health Perspect. 116
Pages: 32-38
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[Journal Article] ERRγtethers strongly bisphenol A and 4-α-cumylphenol in an induced-fit manner.2008
Author(s)
Matsushima. A., Teramoto, T., Okada, H., Liu, X., Tokunaga, T., Kakuta, Y., Shimohigashi, Y.
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Journal Title
Biochem. Biophys. Res. Commun. 373
Pages: 408-413
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[Journal Article] Design synthesis of highly potent antagonist of ORL1 nociceptin receptor.2008
Author(s)
Li, J. Isozaki, K., Okada, K., Matsushima, A., Nose, T., Costa, T., Shimohigashi, Y.
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Journal Title
Bioorg. Med. Chem. 16
Pages: 2635-3664
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[Journal Article] Bisphenol AF is a Full Agonist for the Estrogen Receptor ERα, but a Highly Specific Antagonist for ERβ.
Author(s)
Matsushima, A., Liu, X., Okada, H., Shimohigashi, M., Shimohigashi, Y.
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Journal Title
Environ. Health Perspect. (in press)
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