2009 Fiscal Year Final Research Report
Highly sensitive detection of fluorescence with an optical waveguide substrate and polarized excitation light
| Project/Area Number |
20710098
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Nanomaterials/Nanobioscience
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| Research Institution | Tokyo University of Technology |
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Principal Investigator |
AKIMOTO Takuo Tokyo University of Technology, 応用生物学部, 講師 (90367194)
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| Project Period (FY) |
2008 – 2009
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| Keywords | バイオチップ / 蛍光 |
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| Research Abstract |
Fluorescence from an optical waveguide substrate fabricated with a metal and a dielectric was known to be enhanced more than 100 factors. It has been found in recent year that the fluorescence enhancement depends on the polarization of excitation light. Motivated by this finding, we attempted to develop an instrument for highly sensitive detection of fluorescence employing the polarization dependence of the optical waveguide substrate. As a result, approximately 10-times increase of the sensitivity and S/N ratio could be achieved.
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