2010 Fiscal Year Final Research Report
Synthesis and biological application of antibiotic C1027 chromophore
| Project/Area Number |
20710162
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Living organism molecular science
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| Research Institution | Tohoku University |
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Principal Investigator |
SATO Itaru 東北大学, 大学院・理学研究科, 准教授 (80318196)
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| Project Period (FY) |
2008 – 2010
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| Keywords | エンジイン / クロモプロテイン / 全合成 / C-1027 / ケダルシジン / マデュロペプチン |
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| Research Abstract |
The chromophores of the chromoprotein antibiotics C-1027, kedarcidin, and maduropeptin feature a unique nine-membered enediyne structure in the ansa-macrolide ring and show extremely potent cytotoxicity. Their complicated fused ring systems were synthesized and the total synthesis of (-)-maduropeptin chromophore was achieved, which thereby led to the revision of its stereochemical structure.
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Research Products
(30 results)
