2009 Fiscal Year Final Research Report
Network analysis of signal transduction by quantitative phosphoproteomics
Project/Area Number |
20710168
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Single-year Grants |
Research Field |
Living organism molecular science
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Research Institution | Kyushu University |
Principal Investigator |
MATSUMOTO Masaki Kyushu University, 生体防御医学研究所, 准教授 (60380531)
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Project Period (FY) |
2008 – 2009
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Keywords | シグナル伝達 / システム生物学 / リン酸化 / プロテオミクス |
Research Abstract |
It is well known that cells expresses various responses to extracellular stimuli, but these mechanisms in which distinct stimuli induces specific response remained poorly understood. To resolve this essential issue concerning signal transduction, I established the system for large scale identification and quantification of protein phosphorylations. Using this system, I obtained quantitative time-resolved information about more than 25,000 phosphorylation sites from several cell lines which were treated with various stimulants.
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[Journal Article] Fbxo45, a novel ubiquitin ligase, regulates synaptic activity.2010
Author(s)
Tada, H., Okano, H.J., Takagi, H., Shibata, S., Yao, I., Matsumoto, M., Saiga, T., Nakayama, K. I,. Kashima, H., Takahashi, T., Setou, M., Okano, H
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Journal Title
J. Biol. Chem. 285(6)
Pages: 3840-3849
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[Journal Article] Plasma gelsolin facilitates interaction between beta(2) glycoprotein I and alpha5beta1 integrin.2009
Author(s)
Bohgak, M., Matsumoto, M., Atsumi, T, Kondo, T., Yasuda, S., Horita, T., Nakayama, K.I., Okumura, F., Hatakeyama, S., Koike, T.
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Journal Title
J Cell Mol Med. (in press)
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[Journal Article] Large-scale proteomic analysis of tyrosine phosphorylation induced by TCR or BCR activation reveals new signaling pathways.2009
Author(s)
Matsumoto, M., Oyamada, K., Takahashi, H., Sato, T., Hatakeyama, S., Nakayama, K. I
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Journal Title
Proteomics 9
Pages: 3549-3563
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[Journal Article] Fbxo45 forms a novel ubiquitin ligase complex and is required for neuronal development Mol.2009
Author(s)
Saiga, T., Fukuda, T., Matsumoto, M., Tada, H., Okano, H.J., Okano, H., Nakayama KI
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Journal Title
Cell. Biol. 29
Pages: 3529-3543
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[Journal Article] Nucleolar structure and function are regulated by the deubiquitylating enzyme USP36.2009
Author(s)
Endo, A., Matsumoto, M., Inada, T., Yamamoto, A., Nakayama, K.I., Kitamura, N., Komada, M.
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Journal Title
J. Cell Sci 122
Pages: 678-686
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