2009 Fiscal Year Final Research Report
Investigations of molecular mechanism of Eg5 and inhibitory mechanism of Eg5 inhibitors.
| Project/Area Number |
20710170
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Living organism molecular science
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| Research Institution | Gakushuin University |
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Principal Investigator |
YAJIMA Junichiro Gakushuin University, 理学部, 研究員 (00453499)
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| Research Collaborator |
NISHIZAKA Takayuki 学習院大学, 理学部, 教授 (40359112)
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| Project Period (FY) |
2008 – 2009
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| Keywords | バイオナノマシーン |
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| Research Abstract |
We have discovered that microtubule sliding over surface-attached to single kinesin-5 heads, which is essential for building a mitotic spindle at cell division, rotate at a fixed rate around their long axis. This remarkable observation of a corkscrewing motion of the microtubule was achieved by three-dimensional nanometer resolution optical tracking of a quantum dot attached to the sliding microtubule. The new method uses only one optical component (a prism) without any modification of other aspect of the optical setups.
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