2010 Fiscal Year Final Research Report
Chemical synthesis of unique AG-gangliosides and evaluations of nerve cell stimulation activities
| Project/Area Number |
20710171
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Living organism molecular science
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| Research Institution | The Institute of Physical and Chemical Research |
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Principal Investigator |
HANASHIMA Shinya The Institute of Physical and Chemical Research, 糖鎖構造生物学研究チーム, 基幹研究所研究員 (50373353)
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| Project Period (FY) |
2008 – 2010
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| Keywords | ガングリオシド / 合成 / シアル酸 / NMR |
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| Research Abstract |
Gangliosides isolated from starfish have unique glycan sequences and nerve cell stimulating activities. We focused on their unique glycan sequences and synthesized the glycan parts by developing novel sialylation strategies. Further, we analyzed the binding between a starfish glycan and a protein Siglec, expressing on mammalian cell surfaces and modulating their functions. We elucidated the binding epitope as the trisaccharide unit including the sialic acid residue. Our finding revealed the potential that inner sialic acid could be also recognized by Siglec, which would develop useful potential for inhibitors of Siglec.
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Research Products
(15 results)
