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2009 Fiscal Year Final Research Report

Mechanistic Elucidation of Iron Recognition in Gramineous Plant by using Mugineic Acids Derivatives

Research Project

  • PDF
Project/Area Number 20710173
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Living organism molecular science
Research InstitutionHokkaido University

Principal Investigator

NAMBA Kosuke  Hokkaido University, 大学院・理学研究院, 講師 (50414123)

Project Period (FY) 2008 – 2009
Keywordsムギネ酸 / ムギネ酸・鉄錯体トランスポーター / HvYS1 / ムギネ酸プローブ
Research Abstract

To drive the mechanistic studies of iron recognition in gramineous plant forward, it has been essential to establish efficient methods for mugineic acid derivatives to be utilized as molecular probes. We have recently found that the 2'-hydroxy group can serve as a potential clue for the labeling of mugineic acid analogues. On the basis of this discovery, we have established efficient method for the synthesis of various labeled mugineic acid. All of iron complexes of the synthetic labeled mugineic acid exhibit iron transport abilities through iron transporter. We thus succeed to establish the efficient method for introducing various labels to mugineic acid.

  • Research Products

    (15 results)

All 2010 2009 2008 Other

All Journal Article (10 results) (of which Peer Reviewed: 10 results) Presentation (3 results) Remarks (1 results) Patent(Industrial Property Rights) (1 results)

  • [Journal Article] Toward Mechanistic Elucidation of Iron Acquisition in Barley: Efficient Synthesis of Mugineic Acids and Their Transport Activities2010

    • Author(s)
      Namba, K.; Murata. Y.
    • Journal Title

      The Chemical Record

      Pages: 140-150

    • Peer Reviewed
  • [Journal Article] 4-Aminopyridines-Catalyzed Direct and Regioselective Acylation of N-Tosylhydrazide2009

    • Author(s)
      Namba, K.; Shoji, I.; Nishizawa, M.; Tanino, K.
    • Journal Title

      Org. Lett. 11

      Pages: 4970-4973

    • Peer Reviewed
  • [Journal Article] Toward Palau'amine; Hg(OTf)2-Catalyzed Synthesis of Cyclopentane Core2009

    • Author(s)
      Namba, K.; Kaihara, Y.; Yamamoto, Y.; Imagawa, H.; Tanino, K.; Williams, R.M.; Nishizawa, M.
    • Journal Title

      Chem. Eur. J 15

      Pages: 6560-6563

    • Peer Reviewed
  • [Journal Article] Hg(OTf)2-Catalyzed Instantaneous Hydration of b and d-Hydroxy Internal Alkynes with Complete Regioselectivity.2009

    • Author(s)
      Nishizawa, M.; Takemoto, T.; Sasaki, I.; Nakano, M.; Ho, E.; Namba, K.; Yamamoto, H.; Imagawa, H.
    • Journal Title

      Synlett

      Pages: 1175-1179

    • Peer Reviewed
  • [Journal Article] Silaphenylmercuric Triflate-Catalyzed Reactions: The First Solid Supported Mercuric Salt Catalyst.2009

    • Author(s)
      Yamamoto, H.; Sasaki, I.; Hirai, Y.; Namba, K.; Imagawa, H.; Nishizawa, M. Angew.
    • Journal Title

      Chem. Int. Ed. 48

      Pages: 1244-1247

    • Peer Reviewed
  • [Journal Article] Attempts to Improve the Overall Stereoselectivity of Ireland-Claisen Rearrangement.2009

    • Author(s)
      Chen, C-L.; Namba, K.; Kishi, Y.
    • Journal Title

      Org. Lett. 11

      Pages: 409-412

    • Peer Reviewed
  • [Journal Article] Efficient Glycosylation Using ODS Adsorption Method Based on the Affinity of Long Alkoxybenzyl Glycoside.2008

    • Author(s)
      Imagawa, H.; Kinoshita, A.; Yamamoto, H.; Namba, K.; Nishizawa, H.
    • Journal Title

      Synlett

      Pages: 1981-1984

    • Peer Reviewed
  • [Journal Article] Hg(OTf)2-Catalyzed Cyclization of N-Tosylanilinoallylic Alcohols Leading 2-Vinyindolines.2008

    • Author(s)
      Namba, K.; Nakagawa, Y.; Yamamoto, H.; Imagawa, H.; Nishizawa, M.
    • Journal Title

      Synlett

      Pages: 1719-1723

    • Peer Reviewed
  • [Journal Article] Hg(OTf)2-Catalyzed Aryl Allyl Alcohol Cyclization2008

    • Author(s)
      Namba, K.; Yamamoto, H.; Sasaki, I.; Mori, K.; Imagawa, H.; Nishizawa, M.
    • Journal Title

      Org. Lett. 10

      Pages: 1767-1770

    • Peer Reviewed
  • [Journal Article] A specific transporter for iron (III)-phytosiderophore complex involved iron acquisition by bareley roots.2008

    • Author(s)
      Murata, Y.; Harada, E.; Sugase, K.; Namba, K.; Horikawa, M.; Ma, J. -F.; Yamaji, N.; Ueno, D.; Nomoto, K.; Iwashita, T.; Kusumoto, S.
    • Journal Title

      Pure Appl Chem 80

      Pages: 2689-2697

    • Peer Reviewed
  • [Presentation] ムギネ酸類の実用的合成;イネ科植物収機構解明の鍵2008

    • Author(s)
      難波康祐
    • Organizer
      第43回天然物化学談話会
    • Place of Presentation
      大阪
    • Year and Date
      20080710-20080712
  • [Presentation] Hg(OTf)2触媒を活用したPalau'amineコアの合成2008

    • Author(s)
      難波康祐
    • Organizer
      第14回創薬を目指した生物活性研究会および第43回未来開拓研会合同シンポジウム
    • Place of Presentation
      東京
    • Year and Date
      2008-12-13
  • [Presentation] 実用的な分子変換法開発に基づく複雑な生物活性天然有機化合物の合成2008

    • Author(s)
      難波康祐
    • Organizer
      若手研究者のための有機化学札幌セミナー
    • Place of Presentation
      札幌
    • Year and Date
      2008-10-10
  • [Remarks]

    • URL

      http://barato.sci.hokudai.ac.jp/~oc2

  • [Patent(Industrial Property Rights)] ムギネ酸類の効率的製造方法2008

    • Inventor(s)
      難波康祐、村田佳子
    • Industrial Property Rights Holder
      サントリー株式会社
    • Industrial Property Number
      通常出願・特開4117009
    • Acquisition Date
      2008-04-25

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Published: 2011-06-18   Modified: 2016-04-21  

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