2009 Fiscal Year Final Research Report
Development of a novel anticancer drug targeting UBL-UBA family protein
| Project/Area Number |
20710175
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Living organism molecular science
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| Research Institution | The Institute of Physical and Chemical Research |
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Principal Investigator |
KAWATANI Makoto The Institute of Physical and Chemical Research, 化合物ライブラリー評価研究チーム, 研究員 (50391925)
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| Project Period (FY) |
2008 – 2009
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| Keywords | UBL-UBA型ユビキチンレセプター / 阻害剤 / 癌 |
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| Research Abstract |
The purpose of this study is to develop an anticancer agent targeting UBL-UBA family protein. I found that GUT-70, an antiproliferative compound, binds to ubiquilin 1. GUT-70 accumulated intercellular ubiquitinated proteins, and proteome analysis showed that GUT-70 is classified into the same cluster as a proteasome inhibitor. These results suggest that GUT-70 targets ubiquilin 1, thereby suppressing ubiqutin-proteasome system, resulting in the growth inhibition of cancer cells.
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