2011 Fiscal Year Final Research Report
Reaction-diffusion modeling for intracellular environment
| Project/Area Number |
20740243
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Biophysics/Chemical physics
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| Research Institution | Kobe University (2011)
Osaka University (2008-2010) |
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Principal Investigator |
TOGASHI Yuichi 神戸大学, 大学院・システム情報学研究科, 講師 (50456919)
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| Project Period (FY) |
2008 – 2011
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| Keywords | 生物物理学 / 分子機械 / 細胞 / 超分子混雑 / 自己組織化 / 反応拡散系 / 位相振動子系 / 時空間パターン |
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| Research Abstract |
The activities of biological cells are maintained by chemical reactions. The environment in the cell is however distinct from typical macroscopic reactors ; cells are highly crowded with macromolecules including molecular machines(e. g. enzymes), whose function is coupled with the active molecular motion, and also complex structures such as membranes and cytoskeletons. We investigated how these features of the cell may affect the reaction-diffusion behavior. We found spatiotemporal patterns in which both molecular crowding and machine motion are involved, which suggest significance of molecular "motion" in the cell.
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