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2009 Fiscal Year Final Research Report

Highly Efficient Excess Electron Transfer in Precisely Designed DNA Architectures

Research Project

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Project/Area Number 20750009
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Physical chemistry
Research InstitutionKyoto University

Principal Investigator

ITO Takeo  Kyoto University, 大学院・工学研究科, 助教 (80378801)

Research Collaborator NISHIMOTO Sei-ichi  京都大学, 大学院・工学研究科, 教授 (10115909)
TANABE Kazuhito  京都大学, 大学院・工学研究科, 准教授 (40346086)
YAMADA Hisatsugi  京都大学, 大学院・工学研究科, 助教 (80512764)
Project Period (FY) 2008 – 2009
Keywords生物物理化学・DNA内電子移動 / 核酸 / 時間分解分光測定 / 核酸塩基損傷
Research Abstract

Effects of DNA structure on the DNA-mediated electron transfer efficiency were quantitatively investigated using DNA containing novel photo-induced electron donors. It was suggested that local structural changes and electron affinities of DNA sequences as well as redox properties of the electron donors highly affect the electron transfer efficiency.

  • Research Products

    (10 results)

All 2009 2008 Other

All Journal Article (3 results) (of which Peer Reviewed: 3 results) Presentation (6 results) Remarks (1 results)

  • [Journal Article] Pathways of Excess Electron Transfer in Phenothiazine-tethered DNA Containing Single-base Mismatches2009

    • Author(s)
      Takeo Ito、Akiko Kondo、Tomoyuki Kamashita、Kazuhito Tanabe、Hisatsugu Yamada、Sei-ichi Nishimoto
    • Journal Title

      Org. Biomol. Chem. 7

      Pages: 2077-2081

    • Peer Reviewed
  • [Journal Article] DNA Hairpins Containing a Diaminostilbene Derivative as a Photo-induced Electron Donor for Probing the Effects of Single-Base Mismatches on Excess Electron Transfer in DNA2009

    • Author(s)
      Takeo Ito、Aiko Hayashi、Akiko Kondo、Tsukasa Uchida、Kazuhito Tanabe、Hisatsugu Yamada、Sei-ichi Nishimoto
    • Journal Title

      Org. Lett. 11

      Pages: 927-930

    • Peer Reviewed
  • [Journal Article] Properties and Reactivity of Adenosine Radical Generated by Radiation-Induced Oxidation in Aqueous Solution2009

    • Author(s)
      Takeo Ito、Susumu Kuno、Tsukasa Uchida、Shin-ichi Fujita、Sei-ichi Nishimoto
    • Journal Title

      J. Phys. Chem. 113

      Pages: 389-394

    • Peer Reviewed
  • [Presentation] ジアミノスチルベンを含むDNAにおける電子移動反応の塩基配列依存性2009

    • Author(s)
      内田吏、伊藤健雄、林亜衣子、田邉一仁、山田久嗣、西本清一
    • Organizer
      第24回生体機能関連化学シンポジウム
    • Place of Presentation
      福岡
    • Year and Date
      20090913-20090915
  • [Presentation] ジアミノスチルベンを光誘起電子供与体として含むヘアピン型DNA内過剰電子移動反応2009

    • Author(s)
      伊藤健雄、林亜衣子、内田吏・八田博司、西本清一
    • Organizer
      第89春季年会
    • Place of Presentation
      船橋、千葉
    • Year and Date
      20090327-20090330
  • [Presentation] Photoinduced electro transfer reaction in diaminostilbene- tethered DNA duplexes2009

    • Author(s)
      Takeo Ito、Aiko Hayashi、Tsukasa Uchida、Tanabe Kazuhito、Hisatsugu Yamada、Sei-ichi Nishimoto
    • Organizer
      The 6th International symposium on Nucleic Acids Chemistry
    • Place of Presentation
      akayama、Gifu
    • Year and Date
      2009-09-29
  • [Presentation] Photoinduced excess electron injection into DNA duplexes containing mismatched base pairs2008

    • Author(s)
      Takeo Ito、Akiko Kondo、Aiko Hayashi、Tsukasa Uchida、Kazuhito Tanabe、Sei-ichi Nishimoto
    • Organizer
      Joint Symposium of 18th International Roundtable on Nucleosides, Nucleotides and Nucleic Acids and 35th International Symposium on Nucleic Acids Chemistry
    • Place of Presentation
      Kyoto
    • Year and Date
      20080908-20090912
  • [Presentation] Reductive electron transfer in DNA (2): Synthesis of a New Electron Donor for Investigating Structure-Dependent Electron Transfer in DNA2008

    • Author(s)
      Aiko Hayashi、Takeo Ito、Akiko Kondo、Sei-ichi Nishimoto
    • Organizer
      10th Int. Workshop Radiation Damage to DNA
    • Place of Presentation
      Urabandai、Fukushima
    • Year and Date
      20080108-20080112
  • [Presentation] Reductive electron transfer in DNA (1): Implications for radiation-induced reductive DNA damage 10th Int.2008

    • Author(s)
      Takeo Ito, Akiko Kondo, Tsukasa Uchida, Sei-ichi Nishimoto
    • Organizer
      Workshop Radiation Damage to DNA
    • Place of Presentation
      Urabandai, Fukushima
    • Year and Date
      20080108-20080112
  • [Remarks] ホームページ等

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Published: 2011-06-18   Modified: 2016-04-21  

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