Creation of chiral macromolecules with self-replicating and improving abilities

2010 Fiscal Year Final Research Report

• Project/Area Number: 20750037
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Organic chemistry
• Research Institution: Tokyo University of Science
• Principal Investigator: KAWASAKI Tsuneomi Tokyo University of Science, 総合研究機構, 講師 (40385513)
• Project Period (FY): 2008 – 2010
• Keywords: 不斉自己触媒反応 / ピリミジルアルカノール / 不斉増幅 / デンドリマー / 自己複製 / 自己改善 / ポリスチレン / クリプトキラリティー

Research Abstract

Alkylsilane dendrimers with multi-functionalities of asymmetric autocatalysis were synthesized by the coupling reaction between the dendritic core and pyrimidine moieties. It was found that the chiral dendritic macromolecules possess the ability of the asymmetric autocatalytic self-replication and self-improvement. In addition, the discrimination of cryptochirality of isotactic polystyrene has been achieved in conjunction with asymmetric autocatalysis.

Research Products

• [Journal Article] Discrimination of Cryptochirality in Chiral Isotactic Polystyrene by Asymmetric Autocatalysis (2009)
  • Author(s): Tsuneomi Kawasaki, Christiane Hohberger, Yuko Araki, Kunihiko Hatase, Klaus Beckerle, Jun Okuda, Kenso Soai
  • Journal Title: Chem. Commun. Pages: 5621-5623
  • Peer Reviewed
• [Presentation] 炭素および水素同位体キラル化合物が引き起こす不斉自己触媒反応 (2011)
  • Author(s): 川崎常臣
  • Organizer: 第28回千葉地域活動若手セミナー(招待講演)
  • Place of Presentation: 千葉・東京理科大学野田キャンパス
  • Year and Date: 2011-03-10
• [Presentation] アイソタクチックなポリスチレンオリゴマーを不斉開始剤として用いる不斉自己触媒反応 (2009)
  • Author(s): 荒木裕子・畑瀬國彦・川崎常臣・奥田純・〓合憲三
  • Organizer: 日本化学会第89春季年会
  • Place of Presentation: 船橋・日大工学部船橋キャンパス
  • Year and Date: 20090327-20090330
• [Presentation] Creation of Chiral Dendritic Macromolecules with the Functionalities of Self-Replication and Self-improvement in Combination with Asymmetric Autocatalysis (2008)
  • Author(s): Tsuneomi Kawasaki, Mai Nakaoda, Yutaro Takahashi, Yusuke Kanto, Nanako Kuruhara, Kenji Hosoi, Kenso Soai
  • Organizer: ESF-COST High-Level Research Conference -Systems Chemistry-
  • Place of Presentation: Maratea・Italy
  • Year and Date: 20081003-20081008
• [Remarks] ホームページ等
  • URL: http://www.rs.kagu.tus.ac.jp/soai/KawasakiT_engl.html