2009 Fiscal Year Final Research Report
Development of Chip Electrophoresis-Laser Spray Ionization Mass Spectrometry Using Gold Nanoparticles
| Project/Area Number |
20750060
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Analytical chemistry
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| Research Institution | Kyoto University |
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Principal Investigator |
KITAGAWA Fumihiko Kyoto University, 工学研究科, 講師 (20362452)
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| Project Period (FY) |
2008 – 2009
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| Keywords | マイクロチップ電気泳動 / 質量分析 / レーザースプレーイオン化 / ナノスプレー / 金ナノ微粒子 / 局在プラズモン / 熱レンズ顕微鏡 / シクロオレフィンポリマー |
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| Research Abstract |
In this study, development of laser spray ionization-mass spectrometry (LSIMS) using gold nanoparticles was investigated on nanospray directly integrated electrophoresis chips. A sample solution containing gold nanoparticles was introduced from the nanospray to the MS detector by the infusion mode. When a 532-nm CW-laser was irradiated to the tip of the nanospray, 12-fold increase in the MS signal intensity was observed in the negative mode. Therefore, it was revealed that LSI-MS using gold nanoparticles gave the MS signal enhancements for anionic analytes.
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