2009 Fiscal Year Final Research Report
Development of ultra high-sensitive metabolomics utilizing F-trap derivatization and its application to assessment of pharmacotherapeutic effects
| Project/Area Number |
20750066
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Analytical chemistry
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| Research Institution | Fukuoka University |
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Principal Investigator |
TODOROKI Kenichiro Fukuoka University, 薬学部, 助教 (70341451)
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| Project Period (FY) |
2008 – 2009
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| Keywords | メタボロミクス / HPLC / 蛍光 / 誘導体化 / フルオラス |
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| Research Abstract |
We have developed a F-trap fluorescence derivatization method which enables ultra-sensitive and comprehensive analysis of endogenous amino metabolites. By combining this method and statistical technique, we established an assessment method of pharmacotherapeutic effects of anticancer drugs on tumor cells. Furthermore, we have also developed a fluorous scavenging derivatization (FSD) method which enables ultra-sensitive and comprehensive analysis of organic acid metabolites.
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