2009 Fiscal Year Final Research Report
Pathogen Removal Materials by Glycopolymers
| Project/Area Number |
20750088
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Polymer chemistry
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| Research Institution | Japan Advanced Institute of Science and Technology |
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Principal Investigator |
MIURA Yoshiko Japan Advanced Institute of Science and Technology, マテリアルサイエンス研究科, 准教授 (00335069)
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| Project Period (FY) |
2008 – 2009
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| Keywords | 生体関連高分子 / 糖鎖高分子 / リビング重合 |
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| Research Abstract |
The acrylamide derivatives of sulfonated glucosamine and uronic acid were synthesized as glycosaminoglycan model polymers. The polymers were bound to amyloid β peptides to inhibit the aggregation of peptides. The living radical polymerization of glycopolymers was investigated with RAFT reagents. The living radical polymerization provides the glycopolymers with thiol terminal, which were combined with gold substrates and gold nanoparticles. The glycopolymer hybrid materials showed the specific affinity to protein, pathogen and bacteria.
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