2009 Fiscal Year Final Research Report
A novel heme catabolism : Reaction mechansim and detection from biological systems
| Project/Area Number |
20750125
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Chemistry related to living body
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| Research Institution | Tohoku University |
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Principal Investigator |
MATSUI Toshitaka Tohoku University, 多元物質科学研究所, 講師 (90323120)
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| Project Period (FY) |
2008 – 2009
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| Keywords | ヘム代謝 / 反応機構 / 酸素活性化 / ベルドヘム |
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| Research Abstract |
Heme oxygenase (HO) is an enzyme that catalyzes oxidative heme degradation. We recently have found a novel heme catabolic reaction by HO to produce new products in vitro. In this research project, the HO reactions were extensively studied by means of reaction analysis, structural analysis and theoritical calculation to clarify the novel HO reaction. The new heme catabolite was succesfully detected in mammalian cell culture so that the novel HO reaction can proceed in living organisms.
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