2010 Fiscal Year Final Research Report
Photoswitching of RNA Function by using photoresponsive RNA
| Project/Area Number |
20750132
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Chemistry related to living body
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| Research Institution | Nagoya University |
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Principal Investigator |
LIANG Xingguo Nagoya University, 工学研究科, 准教授 (60447828)
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| Project Period (FY) |
2008 – 2010
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| Keywords | RNA / アゾベンゼン / 光制御 / 光スイッチング / リボザイム |
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| Research Abstract |
By chemically modifying RNA with azobenzene moieties, whose molecular structures change greatly with light irradiation, photoresponsive RNA is prepared. By using the photoisomerization of introduced azobenzene, formation and dissociation of RNA/RNA and RNA/DNA duplex has been photoregulated. Furthermore, multiple azobenzenes have been introduced to a ribozyme with enzymatic activity, and photoswitching of RNA cleavage at a specific site has been realized. The photoresponsive RNA is promising to be used for photoswitching RNA function.
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[Journal Article] Robust and photo-controllable DNA capsules using azobenzenes.2010
Author(s)
Tanaka, F. ; Mochizuki, T. ; Liang, X.G. ; Asanuma, H. ; Tanaka, S. ; Suzuki, K. ; Kitamura, S. ; Nishikawa, A. ; Ui-Tei, K. ; Hagiya, M.
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Journal Title
Nano Lett. 10
Pages: 3560-3565
Peer Reviewed
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[Journal Article]2010
Author(s)
Hara, Y. ; Fujii, T. ; Kashida, H. ; Sekiguchi, K. ; Liang, X.G. ; Niwa, K. ; Takase, T. ; Yoshida, Y. ; Asanuma, H.
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Journal Title
Angew.Chem.Int.Ed. 49
Pages: 5502-5506
Peer Reviewed
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