2009 Fiscal Year Final Research Report
Development of novel nucleic acid analogs that regulate functions of non-coding RNAs
| Project/Area Number |
20750136
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Chemistry related to living body
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| Research Institution | Kyoto Institute of Technology |
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Principal Investigator |
YAMAYOSHI Asako Kyoto Institute of Technology, 工芸科学研究科, 助教 (70380532)
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| Project Period (FY) |
2008 – 2009
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| Keywords | non-coding RNA / 核酸 / アンチセンス / microRNA / 7SK |
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| Research Abstract |
Non-coding RNAs are functional molecules associated with various disease, such as cancers and AIDS, development. We focused on functions of (1) microRNA and (2) 7SK non-coding RNAs. These non-coding RNAs exhibited their function as "RNA-Protein complexes". We developed novel nucleic acid analogs, which inhibit or mimic RNA-Protein interfaces, for the treatment of cancers or AIDS.
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