2009 Fiscal Year Final Research Report
Development of chimeric protein based on the silk fibroin and high calcium binding motifs for bone regeneration.
| Project/Area Number |
20750174
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Polymer/Textile materials
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| Research Institution | Tokyo University of Agriculture and Technology |
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Principal Investigator |
NAKAZAWA Yasumoto Tokyo University of Agriculture and Technology, 工学部, 助教 (20456255)
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| Project Period (FY) |
2008 – 2009
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| Keywords | 絹フィブロイン / 骨再生 / 核磁気共鳴法 / キメラタンパク質 |
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| Research Abstract |
For bone tissue engineering, we produced a new silk-like peptide, En(AGSGAG)m. This model peptide consists of the crystalline region of the silk fibroin from Bombyx mori, (AGSGAG), and a poly-glutamic acid region to improve the water solubility and Ca2+ binding ability. In this study, we performed structural and functional analyses for the molecular design of biomaterials for bone regeneration.
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