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2009 Fiscal Year Final Research Report

Laser Photo-Fabrication of Metallic Nanoparticles in Living Cells

Research Project

  • PDF
Project/Area Number 20760035
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Applied optics/Quantum optical engineering
Research InstitutionOsaka University

Principal Investigator

スミス ニコラス アイザック  Osaka University, 免疫学フロンティア研究センター, 特任講師 (10362592)

Project Period (FY) 2008 – 2009
Keywordsナノ粒子 / フォトファブリケーション / 培養細胞 / 毒性 / 生存能力 / 表面増強ラマン
Research Abstract

This research has found that metal can be fabricated in the salt conditions of the cell, but localization remains difficult, using multiphoton laser irradiation. However, the cells were found to exclude indicator propidium iodide, which is very promising for the future continuation of this work. Using dark-field and luminescence imaging, highly scattering regions were observed around the location of the laser focus, consistent with gold nanoparticles.

  • Research Products

    (5 results)

All 2009 2008

All Journal Article (4 results) Presentation (1 results)

  • [Journal Article] Time-resolved observation of surface-enhanced Raman scattering from gold nanoparticles during transport through a living cell2009

    • Author(s)
      K. Fujita, S. Ishitobi, K. Hamada, N.I. Smith, A. Taguchi, Y. Inouye, S. Kawata
    • Journal Title

      J. Biomed. Opt. PEER REVIEWED VOLUME14,ISSUED

      Pages: 024038

  • [Journal Article] Photogeneration of membrane potential hyperpolarization and depolarization in non-excitable cells2009

    • Author(s)
      J. Ando, NI Smith, K. Fujita, S. Kawata
    • Journal Title

      Eur. Biophys. J. PEER VOLUME38(2)(REVIEWER)

      Pages: 255-262

  • [Journal Article] Optical trapping and surgery of living yeast cells using a single laser2008

    • Author(s)
      J. Ando, G. Bautista, N. Smith, K. Fujita, V.R. Daria
    • Journal Title

      Rev. Sci. Instrum. VOLUME79(PEER REVIEWED)

      Pages: 103705

  • [Journal Article]2008

    • Author(s)
      Keisaku Hamada, Katsumasa Fujita, Nicholas Isaac Smith, Minoru Kobayashi, Yasushi Inouye, Satoshi Kawata
    • Journal Title

      J. Biomed. Opt. VOLUME13(PEER REVIEWED)

      Pages: 044027

  • [Presentation] 生細胞内での金イオン還元による金ナノ粒子の形成2008

    • Author(s)
      森田寛之、新岡宏彦、安藤潤、藤田克昌、河田聡
    • Organizer
      日本生物物理学会年会
    • Place of Presentation
      福岡コンベンションセンター
    • Year and Date
      20081203-20081205

URL: 

Published: 2011-06-18   Modified: 2016-04-21  

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