2009 Fiscal Year Final Research Report
Development of system identification methods for systems biology in yeast
| Project/Area Number |
20760274
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Control engineering
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| Research Institution | Utsunomiya University |
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Principal Investigator |
AZUMA Takehito Utsunomiya University, 工学研究科, 准教授 (60308179)
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| Project Period (FY) |
2008 – 2009
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| Keywords | システムバイオロジー / システム同定 / 酵母 / 細胞分裂 / タンパク質ネットワーク |
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| Research Abstract |
Estimation problems of protein networks are defined for cell cycle in yeast and an approach to solve the problems has been proposed. In our approach, it is assumed that concentrations of proteins for cell cycle are obtained. Based on those concentrations of proteins, state space models are identified and the protein network for cell cycle is estimated. In numerical examples, the efficacy of our approach is demonstrated and the existence of unknown network paths is indicated. Moreover the roles of the estimated and unknown network paths are shown by using sensitivity analysis.
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