2009 Fiscal Year Final Research Report
High-throughput screening for the mitochondrial enzyme that acetylates SOD
| Project/Area Number |
20770009
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Genetics/Genome dynamics
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| Research Institution | The Institute of Physical and Chemical Research |
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Principal Investigator |
TAKAHASHI Hidekazu The Institute of Physical and Chemical Research, 吉田化学遺伝学研究室, 基礎科学特別研究員 (90450402)
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| Project Period (FY) |
2008 – 2009
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| Keywords | アセチル化 / ミトコンドリア / SOD / 活性酸素 / 翻訳後修飾 / 分裂酵母 |
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| Research Abstract |
The mitochondrially-localized superoxide dismutase (SOD) is vital for oxidative stress response. SOD seem to be acetylated at lysine residues. I have studied functional significance and molecular mechanism of the SOD acetylation. I found that two metabolic genes were important for the acetylation of SOD in fission yeast. Reduction in acetylation made SOD slightly more active, but the mutation of the defined acetylated residues did not affect the activity.
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