2009 Fiscal Year Final Research Report
The structural biological study of the macromolecular complex involved with formation of SARS-CoV virions
| Project/Area Number |
20770075
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Structural biochemistry
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| Research Institution | Hokkaido University |
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Principal Investigator |
SAKAI Naoki Hokkaido University, 大学院・先端生命科学研究院, 助教 (20422008)
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| Project Period (FY) |
2008 – 2009
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| Keywords | 構造生物学 / 蛋白質結晶学 / SARSコロナウイルス |
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| Research Abstract |
The aim of this study is elucidating the molecular basis of budding of SARS coronavirus (SARS-CoV). In the initiation stage of a budding of virion from infected host cell, N protein and M protein are interacted. This interaction is considered as a trigger of budding of SARS-CoV. To obtain a detail of the molecular mechanism of this phenomenon, I tried to solve the crystal structure of the macromolecular complex of N and M proteins and established the preparation method of N protein.
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