2009 Fiscal Year Final Research Report
Structural study of new regulatory mechanisms of histone methylation
| Project/Area Number |
20770086
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Structural biochemistry
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| Research Institution | Nara Institute of Science and Technology |
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Principal Investigator |
OHKI Izuru Nara Institute of Science and Technology, バイオサイエンス研究科, 助教 (80418574)
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| Project Period (FY) |
2008 – 2009
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| Keywords | クロマチン構造 / ヒストン修飾 / タンパク質 / 立体構造解析 |
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| Research Abstract |
In vertebrate, histones are modified in various combinations to produce the elaborate transcriptional control. In this study, we focus on the interaction of the trithorax MLL and polycomb Pc proteins to clarify the new regulatory mechanism by histone methylation. From structural analysis, two proteins were found to interact directly through a domain that has the opposite function of each other. This interaction was considered to adjust the balance of transcriptional activation and repression.
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[Journal Article] Molecular basis for E-cadherin recognition by killer cell lectin-like receptor G1 (KLRG1).2009
Author(s)
Nakamura S, Kuroki K, Ohki I, Sasaki K, Maruyama T, Ito M, Kameda Y, Ikura M, Yamamoto K, Matsumoto N, Maenaka K.
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Journal Title
J.Biol.Chem. 284
Pages: 27327-35
Peer Reviewed
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