2009 Fiscal Year Final Research Report
Recognition of presequences of mitochondrial precursor proteins using dynamic equilibrium
| Project/Area Number |
20770087
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Structural biochemistry
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| Research Institution | Kyushu University |
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Principal Investigator |
SAITOH Takashi Kyushu University, デジタルメディシン・イニシアティブ, 助教 (00432914)
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| Project Period (FY) |
2008 – 2009
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| Keywords | 分子認識及び相互作用 |
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| Research Abstract |
In previous study, we proposed that a dynamic equilibrium between the multiple bound states is the molecular mechanism of the broadly selective specificity of the Tom20 receptor towards the divergent mitochondrial presequences. In this study, we carried out X-ray crystal structure analysis and NMR spectroscopy experiments using new complexes between Tom20 and presequenses. We obtained further information supporting the dynamic recognition model.
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Research Products
(4 results)
