2009 Fiscal Year Final Research Report
regulation of acidic organelle localization by V-ATPase
| Project/Area Number |
20770090
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Structural biochemistry
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| Research Institution | Iwate Medical University |
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Principal Investigator |
GOTO Naomi (松元 奈緒美) Iwate Medical University, 薬学部, 助教 (80403971)
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| Project Period (FY) |
2008 – 2009
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| Keywords | V-ATPase / 小胞分泌 |
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| Research Abstract |
Vacuolar type ATPase (V-ATPase) consists of 13 different subunits, and transports protons using energy from ATP hydrolysis. V-ATPase has variety of subunit isoforms, consistent with the different pH in acidic compartment. Previously, we showed that a3, one of 'a' subunit isoforms, was induced during osteoclast differentiation. In this study, we found the induction of d2 isoform and its interaction with a3 in differentiated cells. This interaction suggests that osteoclasts have a novel combination of V-ATPase isoforms.
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