2009 Fiscal Year Final Research Report
Structural basis of antiviral deaminases
| Project/Area Number |
20770094
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Structural biochemistry
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| Research Institution | National Institute of Advanced Industrial Science and Technology |
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Principal Investigator |
SUTO Kyoko 独立行政法人産業技術総合研究所, 生物機能工学研究部門, 研究員 (90415696)
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|---|
| Project Period (FY) |
2008 – 2009
|
| Keywords | タンパク質 |
|---|
| Outline of Final Research Achievements |
Protein-tagged human APOBEC3G and HIV-1 Vif were prepared using an expression system of E. coli. The APOBEC3G had deamination activity and the Vif inhibited it in a dose-dependent manner in vitro. The proteins were purified and used for crystallization screening.
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| Free Research Field |
生物学
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