2009 Fiscal Year Final Research Report
Analysis on the signal transduction pathway by the reconstitution of signaling components
| Project/Area Number |
20770098
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Functional biochemistry
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| Research Institution | The University of Tokyo |
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Principal Investigator |
MIYADERA Hiroko The University of Tokyo, 大学院・医学系研究科, 助教 (40361464)
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| Project Period (FY) |
2008 – 2009
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| Keywords | 細胞情報伝達機構 |
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| Research Abstract |
Tumor necrosis factor (TNF)-related apoptosis-inducing ligand/Apoptosis ligand 2 (TRAIL/Apo2L) induces tumor cell specific apoptosis. In the extracellular domain of TRAILR1, there are two SNPs (H141R and R209T) which were reported to be associated with cancers. We expressed and refolded TRAIL and TRAILR1 recombinant protein in E. coli in order to assess the effects of these polymorphisms to the ligand-receptor interaction.
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