2009 Fiscal Year Final Research Report
Functional analysis of atypical nuclear small GTP-binding protein
| Project/Area Number |
20770103
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Functional biochemistry
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| Research Institution | Nara Institute of Science and Technology |
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Principal Investigator |
TAGO Kenji Nara Institute of Science and Technology, バイオサイエンス研究科, 助教 (20306111)
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| Project Period (FY) |
2008 – 2009
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| Keywords | 細胞情報伝達機構 |
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| Research Abstract |
We found that κB-Ras is a novel type of nuclear-cytoplasmic small GTPase that mainly binds to GTP, and its localization seemed to be regulated by its GTP/GDP-binding state. Unexpectedly, the GDP-binding form of κB-Ras mutant exhibited a more potent inhibitory effect on NF-κB activation, and this inhibitory effect seemed to be due to suppression of the transactivation of a p65/RelA NF-κB subunit.
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