2009 Fiscal Year Final Research Report
Analysis of chondroitin proteoglycans and related molecules involved in cell division control
| Project/Area Number |
20770104
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Functional biochemistry
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| Research Institution | Kyushu University |
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Principal Investigator |
MIZUGUCHI Souhei Kyushu University, 大学院・生命科学研究部, 産学官連携研究員 (50398103)
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| Project Period (FY) |
2008 – 2009
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| Keywords | 糖鎖 / C. elegans / 細胞分裂 |
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| Research Abstract |
Chondroitin proteoglycans are involved in cell division. We analysed chondroitin proteoglycans and related molecules using model organism C. elegans and found following. 1) Two chondroitin proteoglycans are required for proper assembly of the C. elegans eggshell and osmotic barriear. 2) Chondroitin plays an important role on meiosis in nematode germ line. 3) Chondroitin proteoglycans are imvolved in receptor-mediated transport of vitellogenin during oogenesis. These findings suggest that chondroitin and related molecules are involved in cell division control and molecular transport systems.
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