The role of mitochondrial proteins involved in the innate immunity

2009 Fiscal Year Final Research Report

• Project/Area Number: 20770123
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Biophysics
• Research Institution: Kyushu University
• Principal Investigator: KOSHIBA Takumi Kyushu University, 理学研究院, 准教授 (70403970)
• Project Period (FY): 2008 – 2009
• Keywords: ミトコンドリア / RNAウイルス / 自然免疫 / シグナル伝達 / インターフェロン

Research Abstract

Innate cellular immune response to viral infection results in the activation of multiple signaling steps, ultimately regulates the expression of type-I interferons (IFNs), and a mitochondrial membrane protein, MAVS plays an important role in the pathway. In the presence study, we found that mitofusin 2 (Mfn2), a mediator of mitochondrial fusion, cooperates with MAVS, and participates in the antiviral immunity. Our results suggest that Mfn2 acts as a negative regulator for antiviral signaling, and would have a distinct function unrelated to mitochondrial dynamics.

Research Products

• [Journal Article] ミトコンドリア外膜タンパク質Mitofusin 2によるウイルス免疫制御機構. (2010)
  • Author(s): *小柴琢己
  • Journal Title: 実験医学(羊土社) 28 Pages: 429-432
• [Journal Article] ミトコンドリア外膜上でのウイルス免疫制御機構. (2010)
  • Author(s): *小柴琢己
  • Journal Title: 生化学(日本生化学会) 82 Pages: 135-139
• [Journal Article] Mitofusin 2 inhibits mitochondrial antiviral signaling. (2009)
  • Author(s): Yasukawa, K., Oshiumi, H., Takeda, M., Ishihara, N., Yanagi, Y., Seya, T., Kawabata, S., *Koshiba, T.
  • Journal Title: Science Signaling 2 Pages: ra47
• [Presentation] Mitochondrial dynamics in mammalian cells and an insight for antiviral innate immunity (2010)
  • Author(s): Koshiba, T.
  • Organizer: STINT workshop on Invertebrates (Uppsala University, Sweden
  • Year and Date: 20100300
• [Presentation] Mitochondrial dynamics and an insight for antiviral innate immunity (2010)
  • Author(s): Koshiba, T.
  • Organizer: International Symposium "Intercellular Recognition and Allogenic Authentication: Perspectives of Reproduction Mechanisms Shared by Animals and Plants"
  • Place of Presentation: SIR Winston Hotel (Nagoya, Japan)
  • Year and Date: 20100100
• [Presentation] Mitofusin 2 acts as a negative regulator of mitochondrial antiviral immunity (2009)
  • Author(s): Yasukawa, K., Oshiumi, H., Takeda, M., Ishihara, N., Yanagi, Y., Seya, T., Kawabata, S., Koshiba, T.
  • Organizer: 第32回日本分子生物学会年会
  • Place of Presentation: パシフィコ横浜(横浜)
  • Year and Date: 20091200
• [Presentation] Mitofusin 2 acts as an inhibitor of mitochondrial antiviral signaling (2009)
  • Author(s): 小柴琢己
  • Organizer: 第82回日本生化学会大会
  • Place of Presentation: 神戸ポートアイランド(神戸)
  • Year and Date: 20091000
• [Presentation] ミトコンドリア外膜上での自然免疫調節機構 (2009)
  • Author(s): 小柴琢己
  • Organizer: 第9回日本蛋白質科学会年会
  • Place of Presentation: 熊本全日空ホテルニュースカイ(熊本)
  • Year and Date: 20090500
• [Presentation] 自然免疫に関わるミトコンドリア膜蛋白質MAVS機能ドメインの大腸菌による大量発現系構築 (2008)
  • Author(s): 安川開、川畑俊一郎、小柴琢己
  • Organizer: 第31回日本分子生物学会年会
  • Place of Presentation: 神戸ポートアイランド(神戸)
  • Year and Date: 20081200
• [Remarks]
  • URL: http://www.biology.kyushu-u.ac.jp/~koshiba/