2009 Fiscal Year Final Research Report
Functional analysis of kinetochore proteins by utilizing engineered fission yeast cells harboring a single chromosome.
| Project/Area Number |
20770143
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Molecular biology
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| Research Institution | Kurume University |
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Principal Investigator |
SAITOH Shigeaki Kurume University, 分子生命科学研究所, 准教授 (30352123)
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| Project Period (FY) |
2008 – 2009
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| Keywords | 染色体 / キネトコア / 有糸分裂 |
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| Research Abstract |
Kinetochore is a multi-protein complex essential for chromosome segregation. In this research, we constructed "single-chromosome fission yeast", in which all the genomic information is put together on one chromosome. By utilizing this yeast strain, we found that mitotic kinetochore take a special architecture, in which the central domain of the centromere protrudes from the both sides of the "core" consisting of the heterochromatin. We speculate that this special architecture is vital for equal separation of replicated chromosomes.
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