2009 Fiscal Year Final Research Report
Clarification of molecular mechanisms of RANK/TRAF6 signaling pathways in osteoclastogenesis
| Project/Area Number |
20770153
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Cell biology
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| Research Institution | The University of Tokyo |
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Principal Investigator |
GOHDA Jin The University of Tokyo, 医科学研究所, 助教 (90361617)
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| Project Period (FY) |
2008 – 2009
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| Keywords | 発生・分化 / 細胞内シグナル伝達 / 骨代謝 / 破骨細胞 / アダブター分子 |
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| Research Abstract |
Osteoclasts, which are bone-resorbing cells, play a pivotal role in maintenance of bone homeostasis. The formation of osteoclasts requires the signaling pathways mediated by the receptor protein, RANK. In the present study, I demonstrated that RANK has a novel functional domain that sustains its interaction with the downstream signaling factors. Furthermore, Treatment with the peptides containing the amino aid sequence of its domain significantly suppressed osteoclast formation. These findings might contribute to development of new treatments for bone diseases, such as osteoporosis.
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