2009 Fiscal Year Final Research Report
Study on the function of the transcriptional repressor Fbl10 in the regulation of c-Jun
| Project/Area Number |
20770154
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Cell biology
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| Research Institution | The University of Tokyo |
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Principal Investigator |
NASU Ryo The University of Tokyo, 分子細胞生物学研究所, 助教 (30466859)
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| Project Period (FY) |
2008 – 2009
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| Keywords | クロマチン / 細胞周期 / c-Jun / JmjC / HP1 |
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| Research Abstract |
The transcriptional repressor Fbl10 is found to cooperate with Heterochromatin Protein 1 γ (HP1γ) to repress c-jun transcription. Moreover, HP1γ is dispensable for the tumorigenicity of colon cancer cells. Therefore, the increase of c-Jun by HP1γ repression may be involved in the induction of cell death, rather than the promotion of G1/S transition of cell cycle.
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