2009 Fiscal Year Final Research Report
Physiological roles of mitochondrial fission factor Drp1 in mammal.
| Project/Area Number |
20770155
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Cell biology
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| Research Institution | Tokyo Medical and Dental University |
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Principal Investigator |
ISHIHARA Naotada Tokyo Medical and Dental University, 大学院・医歯学総合研究科, 講師 (10325516)
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| Project Period (FY) |
2008 – 2009
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| Keywords | ミトコンドリア / 膜融合 / 膜分裂 / 膜ダイナミクス / オルガネラ |
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| Research Abstract |
Mitochondrial morphology is dynamically controlled by a balance between fusion and fission. Here we show that, even cultured cells lacking the mitochondrial fission GTPase Drp1 are normal, Drp1-KO mice have developmental abnormalities, die after embryonic day 12.5. Neural cell-specific Drp1-KO mice die shortly after birth as a result of brain hypoplasia with apoptosis.
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[Journal Article] Mitochondrial fission factor Drp1 is essential for embryonic development and synapse formation in mice.2009
Author(s)
N. Ishihara, M. Nomura, A. Jofuku, H. Kato, S.O. Suzuki, K. Masuda, H. Otera, Y. Nakanishi, I. Nonaka, Y. Goto, N. Taguchi, H. Morinaga, M. Maeda, R. Takayanagi, S. Yokota, K. Mihara
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Journal Title
Nature Cell Biol. 11
Pages: 958-966
Peer Reviewed
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