2009 Fiscal Year Final Research Report
Role of PSTPIP2, an autoinflammatory disorder-associated protein, in cell migration
| Project/Area Number |
20770158
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Cell biology
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| Research Institution | Kobe University |
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Principal Investigator |
TSUJITA Kazuya Kobe University, 大学院・医学研究科, 助教 (10457054)
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| Project Period (FY) |
2008 – 2009
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| Keywords | 細胞骨格 / 細胞内シグナル伝達ファゴサイトーシス |
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| Research Abstract |
It was shown that PSTPIP2 is a negative regulator of phagocytosis. It is suggested that PSTPIP2 is localized to the nascent cup, where it suppress the robust actin polymerization. The localization of PSTPIP2 to the nascent cup is dependent on its lipid binding ability. In addition, PSTPIP2 is tyrosine phosphorylated following phagocytosis and its phosphorylation dissociates it from the nascent cup. Thus, PSTPIP2 is the novel negative regulator of phagocytosis though inhibiting phagocytic cup formation that is controlled by its tyrosine phosphorylation.
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