2009 Fiscal Year Final Research Report
Analysis of securin and separase functions in mammalian cell cycle regulation.
| Project/Area Number |
20770162
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Cell biology
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| Research Institution | Japanese Foundation For Cancer Research |
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Principal Investigator |
KUMADA Kazuki Japanese Foundation For Cancer Research, 細胞生物部, 研究員 (10370149)
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| Project Period (FY) |
2008 – 2009
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| Keywords | 染色体分配 / DNA損傷応答 / 細胞周期 / ノックアウトマウス / 発がん / 糖尿病 |
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| Research Abstract |
I analyzed the detailed functions of separase and securin proteins in mammalian cell regulation, and found that both proteins cooperatively played another unknown role in DNA damage response, besides the previously well-known one in chromosome separation. I also found that the oncogenic activity of securin protein mainly resulted from the disturbance of its function in chromosome separation.
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