2009 Fiscal Year Final Research Report
Regulatory role of nucleo-cytoplasmic transport in microtubule network organization
| Project/Area Number |
20770164
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Cell biology
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| Research Institution | The Institute of Physical and Chemical Research |
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Principal Investigator |
ARAI Ritsuko The Institute of Physical and Chemical Research, 新分野創造センター, 特任研究員 (10342742)
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| Project Period (FY) |
2008 – 2009
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| Keywords | 微小管 / 核-細胞質間輸送 / レプトマイシンB / Crm1 / importin |
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| Research Abstract |
In fission yeast cells as well as almost all eukaryotic cells, dynamic rearrangement of microtubule structure occurs at the cell cycle transition. I proposed that nucleo-cytoplasmic transport plays a central role in spatio-temporally regulated microtubule network organization. In this model, tubulin and tubulin-associated proteins are actively exported toward outside of the nucleus during interphase, and cytoplasmic microtubule formation is promoted by 'interphase microtubule organizing center', while they imported into the nucleus and mitotic spindle formation is promoted by mitotically activated spindle pole bodies.
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