2010 Fiscal Year Final Research Report
Functions of axon guidance receptors, plexins, in the developing hippocampus
| Project/Area Number |
20770184
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Single-year Grants |
|---|
| Research Field |
Developmental biology
|
|---|
| Research Institution | Tohoku University |
|---|
Principal Investigator |
SUTO Fumikazu Tohoku University, 大学院・医学系研究科, 助教 (40345848)
|
|---|
| Project Period (FY) |
2008 – 2010
|
| Keywords | 神経科学 / 発生生物(学) / 神経発生(学) / 遺伝子 / 発生・分化 / 脳・神経 / 分子局在 / 軸索誘導 |
|---|
| Research Abstract |
We have shown that axon guidance molecule Sema6A and its receptor, plexin-A2 and plexin-A4, regulate the lamina-restricted projection of the hippocampal mossy fibers. We examined the role of semaphoring/plexin signaling in the formation of hippocampal network, and found that the Sema6A/plexin-A4 signaling is required for the sub-dendritc projection of the axons of hippocampal mossy cells. We also identified the molecular domain that is required for the dendritic localization of plexin-A2.
|
Research Products
(6 results)
