2009 Fiscal Year Final Research Report
Epigenetic reprogramming associated with specification and early development of primordial germ cells.
| Project/Area Number |
20770186
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Developmental biology
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| Research Institution | The Institute of Physical and Chemical Research |
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Principal Investigator |
SEKI Yoshiyuki The Institute of Physical and Chemical Research, 理工学部, 専任講師 (20435655)
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| Project Period (FY) |
2008 – 2009
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| Keywords | 生殖細胞 / エピゲノム |
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| Research Abstract |
Birth of life commence with fertilization of sperm and oocyte. Fertilized eggs can from complex and compact body correctly through developmental program. The ability, which one cell can form individual, is called cellular 'totipotency', which is regulated by epigenetic mechanisms. In this research, we focused on epigenetic reprogramming in primordial germ cells to understand how germ cells acquire cellular totipotency. In this result, we identified new gene, Prdm14, and elucidated that Prdm14 deficient mice have infertility in both male and female.
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[Journal Article] Critical function of Prdm14 for the establishment of the germ cell lineage in mice.2008
Author(s)
Yamaji, M. *, Seki, Y. *, Kurimoto, K. *, Yabuta, Y., Yuasa, M., Shigeta, M., Yamanaka., K., Ohinata., Y., Saitou, M.
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Journal Title
Nature Genetics 40(8)
Pages: 1016-1022
Peer Reviewed
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