Directional control of cell polarization revealed by quantitative measurement and mathematical modeling

2010 Fiscal Year Final Research Report

• Project/Area Number: 20770187
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Developmental biology
• Research Institution: The Institute of Physical and Chemical Research
• Principal Investigator: ARATA Yukinobu The Institute of Physical and Chemical Research, 佐甲細胞情報研究室, 研究員 (40360482)
• Project Period (FY): 2008 – 2010
• Keywords: 画像解析プログラム / 数理モデル / 細胞極性 / 方向制御

Research Abstract

Cells polarize along with the axes of the animal body. Cell polarity is maintained by dynamic equilibrium of protein movements. In this study, I succeeded to apply and develop the new systems to reveal protein dynamics quantitatively to developmental biology (Edge-detection image processing program, Fluorescence correlation spectroscopy (FCS), Total internal reflection fluorescence microscope (TIRFM)). Based on the achievements of this study, I will carry out mathematical modeling to understand cell polarization as a dynamical system.

Research Products

• [Journal Article] Extracellular control of PAR protein localization during asymmetric cell division in the C. elegans embryo (2010)
  • Author(s): Arata Yukinobu, Lee Jen-Yi, Goldstein Bob, Sawa Hitoshi
  • Journal Title: Development
• [Presentation] (2010)
  • Organizer: 第48回日本生物物理学会年会
  • Place of Presentation: 宮城
  • Year and Date: 20100920-20100922
• [Presentation] (2009)
  • Organizer: 第82回日本生化学会大会
  • Year and Date: 20091021-20091024
• [Presentation] (2009)
  • Organizer: 17th International C. elegans Meeting
  • Year and Date: 20090624-20090628
• [Presentation] (2009)
  • Organizer: 日本発生生物学会第42回大会
  • Place of Presentation: 新潟
  • Year and Date: 20090528-20090531
• [Remarks]
  • URL: http://www.riken.jp/cell-info/