2009 Fiscal Year Final Research Report
Functional analysis of amino-acid-homopolymer synthetase
| Project/Area Number |
20780057
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Applied microbiology
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| Research Institution | Fukui Prefectural University |
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Principal Investigator |
HAMANO Yoshimitsu Fukui Prefectural University, 生物資源学部, 講師 (50372834)
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| Project Period (FY) |
2008 – 2009
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| Keywords | アミノ酸ホモポリマー / ポリアミド / 非リボソームペプチド合成酵素 / ペプチド / 放線菌 |
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| Research Abstract |
epsilon-Poly-L-Lysine (ε-PL) produced by microorganisms is a highly safe antibacterial substance used widely as one of the world's few natural food preservatives. Although ε-PL has a simple polymer structure consisting of a normal chain of lysine, an amino acid, how it is synthesized inside microorganisms had not been clarified. In this study, we characterized the ε-PL synthetase and its gene. We also revealed that the ε-PL synthetase has a highly unusual domain architecture and reaction mechanism (Nature Chemical Biology, 4, 766-772, 2008).
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[Presentation] Biosynthesis of streptothricin2009
Author(s)
Chitose Maruyama, Junya Toyoda, Aika Yano, Yshimitsu Hamano
Organizer
15th International Symposium on the Biology of Actinomycetes (ISBA)
Place of Presentation
Shanghai (CHINA)
Year and Date
20090800
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