2009 Fiscal Year Final Research Report
Research on the biological function of intracellular aquaporins.
| Project/Area Number |
20780090
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Food science
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| Research Institution | The University of Tokyo |
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Principal Investigator |
OKADA Shinji The University of Tokyo, 大学院・農学生命科学研究科, 助教 (50376563)
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| Project Period (FY) |
2008 – 2009
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| Keywords | アクアポリン / 水チャネル / 嚢胞症 / 組織化学 / 小胞体ストレス / 細胞増殖 / アポトーシス / AQP11 |
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| Research Abstract |
The phenotypes of Aquaporin-11 knockout mice were analyzed by histological methods. Cysts formation was observed in the kidney, but no apparent changes were observed in the stomach, small intestine, liver and spleen of the knockout mice. About 20% of the genes expressing in the kidney were changed in their expression in the knockout mice. By the profiling of the expression changes, the mechanisms of the formation of cysts in the kidney of Aquaporin-11 knockout mice were revealed.
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[Journal Article] Aquaporin-11 knockout mice and polycystic kidney disease animals share a common mechanism of cyst formation.2008
Author(s)
Okada, S., Misaka, T., Tanaka, Y., Matsumoto, I., Ishibashi, K., Sasaki, S., Abe, K.
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Journal Title
FASEB J. 22
Pages: 3672-3684
Peer Reviewed
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[Journal Article] Amiloride reduces the sweet taste intensity by inhibiting the human sweet taste receptor.
Author(s)
Imada, T., Misaka, T., Fujiwara, S., Okada, S., Fukuda, Y., Abe, K.
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Journal Title
Biochem. Biophys. Res. Commun. (in press)
Peer Reviewed
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